The skin microbiome is the ecosystem of microbes that live on our skin. Research is showing that the skin microbiome plays a crucial role in how our skin looks, feels, and acts. Our skin harbours millions of ‘friendly’ microbes, that protect us day in-and-out. Modern technologies help us to determine the effect of cosmetics, soaps, personal care products, antibiotics, probiotics or other interventions on the skin microbiome. However, challenges remain in skin microbiome projects and data interpretation. For this reason BaseClear routinely organises expert meetings wherein scientists, researchers and application specialist meet, share and discuss microbiome projects, challenges and opportunities.